Fig. 1: Mechanisms supporting T-ALL in the thymus microenvironment.

The thymic TME promotes survival and proliferation of T-ALL cells by providing pro-leukemic signals such as IL-7, NOTCH ligands, and IGF1.
The thymic TME promotes survival and proliferation of T-ALL cells by providing pro-leukemic signals such as IL-7, NOTCH ligands, and IGF1.