Fig. 4: Mechanisms supporting T-ALL in the central nervous system.

Multiples signals provided by the CNS TME, such as CCL19/21 and CXCL12, support entry and/or survival of T-ALL blasts.
Multiples signals provided by the CNS TME, such as CCL19/21 and CXCL12, support entry and/or survival of T-ALL blasts.