Fig. 6: Upregulation of Trib3 expression in BAT from mice with diet-induced obesity. | Experimental & Molecular Medicine

Fig. 6: Upregulation of Trib3 expression in BAT from mice with diet-induced obesity.

From: Diet-induced obesity and aging-induced upregulation of Trib3 interfere with energy homeostasis by downregulating the thermogenic capacity of BAT

Fig. 6

a mRNA and (b) protein expression levels of Trib3 in BAT from normal chow-fed and 60% high-fat-diet-fed mice. c mRNA and (d) protein expression levels of Trib3 in preadipocyte cell lines after free fatty acid (FFA) treatment. e Protein and f mRNA expression levels of Trib3 in preadipocyte cell lines after TPA treatment. g Protein expression levels of Trib3 in the absence or presence of COP1 and DET1. h Increased ubiquitination of Trib3 by COP1 and DET1 coexpression. i Resistance to COP1- and DET1-mediated downregulation of Trib3-VP mutant protein levels. j Resistance to COP1- and DET1-stimulated downregulation of Trib3 protein levels by TPA treatment.

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