Fig. 3
From: Sema3A secreted by sensory nerve induces bone formation under mechanical loads
Sema3A from trigeminal ganglion serves as a key signal in late stage of OTM. a, b Immunofluorescence showed that NGF in the trigeminal ganglion increased rapidly before the 3rd day of OTM and then gradually decreased (a), while Sema3A in the trigeminal ganglion gradually increased after the 3rd day of OTM (b). c, d Immunofluorescence showed that NGF in the periodontal tissue increased rapidly before the 3rd day of OTM and then gradually decreased (c), while Sema3A in periodontal tissue increased gradually after the 3rd day of OTM (d). The co-localization with the CGRP+ nerve in periodontal tissue were indicated by white arrow
