Fig. 2: ATF3 over-expression inhibited melanoma cell growth, migration and invasion.
From: ATF-3 expression inhibits melanoma growth by downregulating ERK and AKT pathways
A, B, and C EdU incorporation assay in A2058 and C8161 ATF3 overexpression cell lines. The nuclei of EdU-positive cells were labeled red and cell nuclei were labeled blue with DAPI. The column summarized the staining scores of EdU-positive cells. Scale bar represent 100 μm. D CCK-8 assay in A2058 and C8161 ATF3 overexpression cell lines. E and F Cell colony assay in A2058 and C8161 ATF3 overexpression cell lines. The column summarized the colonies of the cells. G and H Wound healing assay in A2058 and C8161 ATF3 overexpression cell lines. The column summarized the healing percentages compared with NEO control group. Scale bar represent 100 μm. I and J Transwell assay for A2058 and C8161 ATF3 overexpression cell lines invasion tests. The column summarized the invaded cells. Scale bar represent 100 μm. Data are presented as the mean ± standard deviation, **p < 0.01.
