Fig. 7: IL-37b attenuated tumor metastasis in the peritoneal metastatic xenograft model of endometrial cancer. | Laboratory Investigation

Fig. 7: IL-37b attenuated tumor metastasis in the peritoneal metastatic xenograft model of endometrial cancer.

From: IL-37bΔ1-45 suppresses the migration and invasion of endometrial cancer cells by targeting the Rac1/NF-κB/MMP2 signal pathway

Fig. 7

A, B In vivo imaging technique showed that the LV-IL-37bΔ1-45 group had a significantly reduced tumor metastasis compared with the LV-NC group. The bioluminescence was quantified by determining the total flux (photons/sec; p/s) in each ROI. Data acquired from supine (A) and prone (B) views were shown. Data were represented as mean ± SD. n = 10 for each group (p < 0.05). C Image results of liver, kidney, and lung confirmed that IL-37bΔ1-45 could significantly decrease liver metastasis. The bioluminescence quantification represented that IL-37bΔ1-45 inhibited liver metastasis (p < 0.05). *p < 0.05; **p < 0.01.

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