Fig. 2: Retinal function of apoB100 mice with age. | Laboratory Investigation

Fig. 2: Retinal function of apoB100 mice with age.

From: Characterization and identification of measurable endpoints in a mouse model featuring age-related retinal pathologies: a platform to test therapies

Fig. 2

Averaged ERG responses in 8–10-month-old (black) and 17–21-month-old (red) dark-adapted apoB100 mice (red) (n = 5 per group). Plots of A photopic a-wave amplitudes, B photopic b-wave amplitudes, C photopic b-wave/a-wave ratio, D scotopic a-wave amplitudes, and E scotopic b-wave amplitudes and F scotopic b-wave/a-wave ratio are shown as a function of flash intensity (for some points, the error bars are shorter than the height of the symbol). Data points are mean and SEM. *p < 0.01. G Representative ERG traces from 8–10-month-old (black) and 17–21-month-old (red) dark-adapted apoB100 mice. H Averaged c-wave amplitudes in 8–10-month-old (n = 11) and 17–21-month-old (n = 5) apoB100 mice at a flash intensity of 0.2 cd.s/m2. Data points are mean ± SEM (8–12 month, n = 11, 17–21 month, n = 5, *p < 0.05).

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