Fig. 4: FBXW7 enhanced the radiosensitivity of NSCLC cells by inhibiting SOX9 expression. | Laboratory Investigation

Fig. 4: FBXW7 enhanced the radiosensitivity of NSCLC cells by inhibiting SOX9 expression.

From: E3 ubiquitin ligase FBXW7 enhances radiosensitivity of non-small cell lung cancer cells by inhibiting SOX9 regulation of CDKN1A through ubiquitination

Fig. 4

FBXW7 and SOX9 were overexpressed in NCI-H1299R cells. A SOX9 expression was detected using western blot. B CCK-8 assay was used to detect the cell proliferation curve after 6 Gy dose of X-ray radiation. C γ-H2AX was detected using immunofluorescence, scale bars: 10 μm. The cell experiment was conducted 3 times independently. Data were presented as mean ± standard deviation. Data in A/C were analyzed using one-way ANOVA, and data in B were analyzed using two-way ANOVA, followed by Tukey’s multiple comparison test, *p < 0.05.

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