Fig. 4
PD-L1/PD-L2 genetic alterations associated with EBV infection. a Proportion of EBV DNA reads to total mapped reads according to lymphoma subtype (offset, 0.0001). Each dot represents a single case. Red line indicates the cut-off value (0.00015%) for EBV positivity. Type of genetic alterations involving PD-1 ligands is indicated by color. Multiple represents cases harboring both PD-L1 and PD-L2 SVs. b–d Frequency of genetic alterations involving PD-L1/PD-L2 according to EBV status in DLBCL (b), PTCL-NOS (c), and stomach adenocarcinoma (d). Fisher’s exact test is used for DLBCL and PTCL-NOS, and Cochran–Armitage trend test is applied to stomach adenocarcinoma. EBV high group corresponds to the EBV-positive group in the TCGA classification of stomach adenocarcinoma [38]
