Fig. 6
Ikaros induces de novo formation of super-enhancers. a Super-enhancers at day 0 (black) and day 1 (red). Enhancer regions are plotted in increasing order based on their input-normalized H3K4me1 ChIP-Seq signal. Super-enhancers are defined as the population of enhancers above the inflection point of the curve. b The number of super-enhancers at day 0 (black) and day 1 (red). The number of super-enhancers at day 1, with Ikaros binding (orange) or not (blue). c Examples of newly formed, Ikaros-bound, super-enhancers. d Higher expression of the genes in close proximity to super-enhancers vs. the genes near total enhancers—including both super-enhancers and regular enhancers. e, f Gene ontology and pathway enrichment analysis of genes associated with super-enhancers
