Fig. 5: Assessment of a Ca²⁺ channel drug (isradipine) with the EMS model.

a Typical extracellular potential and mechanical beating signals of cardiomyocytes under isradipine treatment at different concentrations (4.1 nM, 12.3 nM, 37.4 nM, 111 nM, 333 nM). b Statistical analysis of five feature parameters of extracellular potential signals under isradipine treatment at five different concentrations. c Statistical analysis of the feature parameters of mechanical beating under isradipine treatment at concentrations of 4.1 nM, 12.3 nM and 37.4 nM. d Statistical analysis of feature parameter EMS signals under isradipine treatment at concentrations of 4.1 nM, 12.3 nM and 37.4 nM (n = 4)