Table 2 The association of PGS for lithium variants and treatment response to lithium in patients with BD at different sample splits.

80%/20%

2083/284

1.31(1.19,1.43)

1.39(1.26, 1.54) ^¥

1.15(1.11, 1.20)

1.17(1.13, 1.22)

Li⁺_PGS by decile

^§R/N

First (lowest score)

44/236

1[Reference]

1[Reference]^¥

1[Reference]

1[Reference]

Second

60/237

1.48(0.96, 2.30)

1.59(1.02, 2.49)

0.94(0.79,1.12)

0.96(0.81,1.15)

Third

54/237

1.29(0.82, 2.02)

1.32(0.84, 2.08)

1.07(0.90,1.28)

1.14(0.95,1.35)

Fourth

70/237

1.83(1.19, 2.83)

1.87(1.21, 2.91)

1.09(0.92,1.31)

1.14(0.96,1.36)

Fifth

59/236

1.45(0.94, 2.27)

1.50(0.96, 2.35)

1.12(0.93,1.34)

1.17(0.98,1.40)

Sixth

62/237

1.55(1.00, 2.40)

1.83(1.17, 2.87)

1.22(1.02,1.46)

1.31(1.09,1.55)

Seventh

76/237

2.06(1.35, 3.17)

2.27(1.48, 3.53)

1.15(0.96,1.38)

1.23(1.04,1.48)

Eighth

68/237

1.76(1.14, 2.72)

1.91(1.23, 2.99)

1.12(0.93,1.34)

1.17(0.98,1.39)

Nineth

78/237

2.14(1.41, 3.29)

2.33(1.51, 3.64)

1.45(1.21,1.72)

1.55(1.31,1.86)

Tenth (highest score)

89/236

2.64(1.74, 4.05)

3.47(2.22, 5.47)

1.52(1.27,1.82)

1.67(1.39,1.99)