Table 2 Epigenome-wide significant (FDR < 0.05) CpGs identified in EWAS meta-analyses for lifetime cannabis use from Model 2, adjusted for cigarette smoking.
CpG | Chr:Position (hg19) | Closest genes | Locationa | Model 2 in all participants (N = 9436) | Model 1 in all participants (N = 9436) | Model 1 in participants who never smoked cigarettes (N = 4146) | EWAS meta-analysis of cigarette smoking [48] (current vs. non-current) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Direction | Effectb | P-value | Effectb | P-value | Effectb | P-value | Effectc | Direction | P-value | ||||
cg01101459 | 1:234871477 | LINC01132 | TFBS | −+−−−+−−−− | −0.0042 | 3.90E-07 | −0.0030 | 2.27E-04 | −0.0034 | 0.0064 | 0.18 | +++−+ | 0.014 |
cg22572071 | 6:47074382 | ADGRF1 | Enhancer | ++++++++++ | 0.0040 | 1.09E-07 | 0.0028 | 9.51E-05 | 0.0024 | 0.025 | 0.0074 | +−+−+ | 0.91 |
cg15280358 | 10:127904472 | ADAM12 | Gene body | +−++?++++− | 0.0058 | 5.15E-07 | 0.0044 | 8.32E-05 | 0.0040 | 0.016 | −0.11 | +−−−+ | 0.22 |
cg00813162 | 14:69443362 | ACTN1 | 5′UTR | −+−−−−−−−− | −0.0028 | 2.46E-07 | −0.0024 | 5.51E-06 | −0.0025 | 0.0019 | 0.023 | ++−?+ | 0.69 |
cg14237301 | 16:28506477 | APOBR | 1st Exon; 5′ UTR | −−−−−−−?− | −0.0040 | 1.76e-05 | −0.0032 | 3.10E-4 | −0.0071 | 9.05E-08 | 0.070 | −++++ | 0.37 |
