Fig. 5: FoxO1 negatively regulates B10 cell differentiation by suppressing Prdm1 expression. | Mucosal Immunology

Fig. 5: FoxO1 negatively regulates B10 cell differentiation by suppressing Prdm1 expression.

From: FoxO1 suppresses IL-10 producing B cell differentiation via negatively regulating Blimp-1 expression and contributes to allergic asthma progression

Fig. 5

a tSNE plot of B cells of mouse lung (GSE132042) and gene expression of Foxo1, Prdm1, and Il10; (b) tSNE plot of B cells of human lung (PRJEB31843) and gene expression of FOXO1, PRDM1, and IL10: (c) Heatmap of the expression of Foxol, Prdm1, and Il10 in different B cell clusters; (d) Heatmap of the expression of FOXO1, PRDM1, and IL10 in different B cell clusters; (e) Il10 and Prdm1 expression of B cells stimulated with LPS, AS1842856 or in combination for 24 h; (f) I110 and Prdm1 expression of B cells stimulated with LPS, in combine with AS1342656 or Prdm1 shRNA for 48 h. Data in (e) and (f) are pooled from two independent experiments *p < 0.05, ***p < 0.01, ***p < 0.001.

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