Fig. 1 | Neuropsychopharmacology

Fig. 1

From: Augmenting extinction learning with d-cycloserine reduces return of fear: a randomized, placebo-controlled fMRI study

Fig. 1

Experimental design and paradigm. a Healthy participants were enrolled in a double-blind, placebo-controlled design with three experimental sessions—Pavlovian conditioning, extinction, and extinction recall—spaced approximately 24 h apart to allow consolidation between sessions. An oral dose of 50 mg of DCS or placebo was administered 1 h before extinction training. b Exemplary trial: In each trial, a CS was presented for 5 s, followed by a jittered ITI (range: 7.7–16.2 s). In case of a CS+ trial during acquisition, the US (aversive panic scream, 2 s duration) appeared simultaneously with CS+ offset (100% reinforcement schedule)

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