Table 2 Differences in cortical thickness between medication-free patients with major depressive disorder and healthy controls

Region	MNI coordinate			SDM Z score	P, uncorrected	Voxels	Cluster breakdown (voxels)
Region	x	y	z	SDM Z score	P, uncorrected	Voxels	Cluster breakdown (voxels)
Patients with major depressive disorder > healthy controls
Left posterior cingulate cortex	0	−24	34	1.113	0.00135	471	Left posterior cingulate/paracingulate gyri, BA 23 (206)
							Right posterior cingulate/paracingulate gyri, BA 23 (141)
							Median network, cingulum (124)
Right ventromedial prefrontal cortex	8	50	2	1.178	0.00087	208	Right superior frontal gyrus, medial, BA 10 (91)
							Left anterior cingulate/paracingulate gyri, BA 24, 32 (85)
							Left median network, cingulum (23)
							Right anterior cingulate/paracingulate gyri, BA 10, 24, 32 (9)
Patients with major depressive disorder < healthy controls
Left gyrus rectus	−4	32	−26	−1.412	0.00027	629	Left gyrus rectus, BA 11 (491)
							Left superior frontal gyrus, orbital part, BA 11 (78)
							Left superior frontal gyrus, medial orbital, BA 11 (47)
							Right gyrus rectus, BA 11 (13)
Right middle temporal gyrus	46	−72	10	−1.144	0.00146	89	Right middle temporal gyrus, BA 19, 37, 39 (78)
Right middle temporal gyrus	46	−72	10	−1.144	0.00146	89	Right middle occipital gyrus, BA 19, 37 (11)
Left superior frontal gyrus, orbital part	−16	58	−8	−1.162	0.00132	63	Left superior frontal gyrus, orbital part, BA 11 (60)
Left superior frontal gyrus, orbital part	−16	58	−8	−1.162	0.00132	63	Left middle frontal gyrus, orbital part, BA 11 (3)

BA Brodmann area, MNI Montreal Neurological Institute, SDM seed-based d mapping

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