Fig. 4: Effects of intrahippocampal Reelin and CNQX-treatment on hippocampal neurogenesis. | Neuropsychopharmacology

Fig. 4: Effects of intrahippocampal Reelin and CNQX-treatment on hippocampal neurogenesis.

From: Fast-acting antidepressant-like effects of Reelin evaluated in the repeated-corticosterone chronic stress paradigm

Fig. 4

CORT had significant effects on hippocampal neurogenesis. a Representative photomicrographs of doublecortin expression in the granule cell/subgranular zone (scale bar = 200 μm). A higher magnification image is shown in the insets (scale bar = 50 μm). b Effects of treatment on the number of doublecortin-ir cells in the granule cell/subgranular zone. Overall, CORT-treated rats had significantly fewer doublecortin-ir cells than CORT Reelin single and CORT Reelin single CNQX-treated rats in the ipsilateral hemisphere (p values <0.05). c Quantified categorization of dendritic complexity using doublecortin staining. All data are represented as means ± standard error of the mean. VRS vehicle Reelin single, CRS CORT Reelin single, VRCNQX vehicle Reelin single CNQX, CRCNQX CORT Reelin single CNQX.

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