Table 2 Regions showing differences in nodal centralities between bipolar and health subjects across different time points.

		P Values
Brain regions	Nodal degree	Nodal efficiency	Nodal betweenness
Baseline
R Inferior frontal gyrus, triangular	0.934	0.820	<0.001 ↓
R Inferior frontal gyrus, orbital	0.027 ↑	0.029 ↑	0.007 ↑
L Superior frontal gyrus, medial orbital	0.055	0.251	0.044 ↑
R Superior frontal gyrus, medial orbital	0.050 ↑	0.043 ↑	0.092
L Anterior cingulate and paracingulate gyri	0.159	0.044 ↑	0.678
R Median cingulate and paracingulate gyri	0.451	0.320	0.042 ↑
L Posterior cingulate gyrus	0.224	0.044 ↓	0.583
L Parahippocampal gyrus	0.289	0.384	<0.001 ↓
R Postcentral gyrus	<0.001 ↓	<0.001 ↓	0.023 ↓
R Superior parietal gyrus	<0.001 ↓	<0.001 ↓	0.142
L Caudate	0.087	0.119	0.035 ↑
L Temporal pole: middle temporal gyrus	0.014 ↑	0.063	0.829
Week 1
R Inferior frontal gyrus, triangular	0.133	0.104	0.016 ↓
R Superior frontal gyrus, medial orbital	0.331	0.046 ↑	0.047 ↑
R Anterior cingulate and paracingulate gyri	0.652	0.034 ↑	0.056
L Posterior cingulate gyrus	0.904	0.174	0.046 ↓
R Postcentral gyrus	0.562	<0.001 ↓	<0.001 ↓
L Putaman	0.529	0.003 ↑	<0.001 ↑
R Middle temporal gyrus	0.021 ↓	0.641	0.955
L Temporal pole: middle temporal gyrus	0.034 ↓	0.835	0.933
Week 8
R Inferior frontal gyrus, triangular	0.295	0.412	0.010 ↓
L Posterior cingulate gyrus	0.691	0.685	0.012 ↓
L Amygdala	0.026 ↓	0.908	0.909
L Caudate	0.015 ↑	0.019 ↑	0.157
R Caudate	0.603	0.047 ↑	0.105
L Putaman	0.653	0.032 ↑	0.133

Regions were considered abnormal in the bipolar subjects if they exhibited significant between-group differences (P < 0.05, uncorrected) in any one of the three nodal centralities (shown in bold font). All brain regions are from automated anatomical labeling (AAL). ↑ , bipolar subjects showed greater nodal centralities than control subjects; ↓, bipolar subjects showed lower nodal centralities than control subjects.

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