Fig. 1

CMG2 is highly expressed in GC tissues and correlated with the outcome of patients. a Representative IHC images of CMG2. Scale bar = 100 μm. aa Absence of CMG2 expression in normal gastric mucosa. ab–d CMG2 staining was observed in GC tissues and the intensity was increased with the tumor invasion depth. ae CMG2 highly expressed in both primary tumor and the corresponding metastatic lymph node. b Higher percentage of CMG2+staining in GC tissues; ***P < 0.001. c, d CMG2 expression at protein and mRNA levels in four fresh surgical gastric tumor specimens (T) and paired adjacent normal tissues (N) detected by western blotting and qRT-PCR, respectively; **P < 0.01, *P < 0.05. e Data in the GEO database GES13911 showing higher CMG2 expression in GC tumor tissues compared to adjacent normal tissues; **P < 0.01. f Kaplan–Meier estimation indicating shorter overall survival time of patients with CMG2+ GC