Fig. 4
From: A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer
The PBK-regulated transcriptional programme in PrCa. a Heatmap showing differentially expressed genes from RNAseq analysis of PBK inhibitor (PBKi) and vehicle control (DMSO) treated C4-2 prostate cancer cells. Heatmap shows z-scores and known AR-regulated genes are highlighted in red and with arrows. b Barplot showing significance testing of the overlaps between PBK inhibitor or PBK knockdown and AR gene sets. Bonferroni corrected p values from hypergeometric tests are plotted as inverse log-values. c Venn diagrams showing the overlap between PBK and AR-regulated genes (overlaps used to calculate p values in c. d Gene set enrichment analysis (GSEA) plots showing the enrichment of AR gene sets in the PBK inhibitor and PBK knockdown ranked expression profiles
