Table 1 PK parameters of ARVib in SD rats’ plasma.
From: ARVib suppresses growth of advanced prostate cancer via inhibition of androgen receptor signaling
Pharmacokinetic parameters | Nic p.o. (200 mg/Kg) | ARVib-7 p.o (200 mg/Kg) | ARVib-31 p.o (200 mg/Kg) |
|---|---|---|---|
HL_Lambda_z (min) | 328.09 ± 173.05 | 580.54 ± 86.4 | 276.51 ± 92.17 |
T max (min) | 25.00 ± 8.66 | 22.5 ± 10.61 | 25 ± 8.66 |
Cmax (nM) | 1556.93 ± 974.31 | 9038.31 ± 8015.51 | 2685.82 ± 1796.25 |
Clast | 14.41 ± 10.83 | 311.67 ± 46.8 | 15.24 ± 5.73 |
AUClast | 248,249.95 ± 91,856.79 | 1,439,633.38 ± 89,486.89 | 382,230.2 ± 220,077.03 |
AUCINF_obs | 170,3577.65 ± 89,354.18 | 256,881.89 ± 167,532.07 | 388,512.79 ± 217,228.83 |
AUC_%Extrap_obs | 3.67 ± 3.73 | 15.35 ± 3.08 | 2.3 ± 1.85 |
