Fig. 5: GPx2 knockdown suppressed GC invasion and migration by promoting KYNU-mediated kynurenine metabolism. | Oncogene

Fig. 5: GPx2 knockdown suppressed GC invasion and migration by promoting KYNU-mediated kynurenine metabolism.

From: Glutathione peroxidase 2 knockdown suppresses gastric cancer progression and metastasis via regulation of kynurenine metabolism

Fig. 5

A GPx2, KYNU and AhR expression was detected by Western blotting following GPx2 knockdown. B, C Quantitation of the Western blotting data. D, E Results of ELISA following GPx2 knockdown. F GPx2 and AhR expression was detected by Western blotting after treatment with kyn (150 μM) for 24 h in GPx2 knockdown GC cell lines. G, H Transwell assays were performed after treatment with kyn (150 μM) or PBS for 24 h in GPx2 knockdown GC cell lines (scale bar, 50 μm). I–L Quantitation of the data from transwell assays. *P < 0.05, **P < 0.01.

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