Fig. 1: FOXK2 was screened as a key transcription factor that regulates glycolysis in OC. | Oncogene

Fig. 1: FOXK2 was screened as a key transcription factor that regulates glycolysis in OC.

From: Phosphorylation of FOXK2 at Thr13 and Ser30 by PDK2 sustains glycolysis through a positive feedback manner in ovarian cancer

Fig. 1

A The mRNA expression of nine key glycolytic enzymes in normal ovary from GTEx (n = 88) and ovarian cancer from TCGA (n = 428). B Genetic alteration of nine key glycolytic enzymes from public databases in the cBioPortal for Cancer Genomics. C Prediction of the transcription factors of nine key glycolysis enzymes through the JASPAR website. The shared five transcription factors of the top 50% high score transcription factors of nine key glycolytic enzymes and their mRNA expression in normal ovary from GTEx (n = 88) and ovarian cancer from TCGA (n = 428). D–L The correlation analysis of FOXK2 and 9 key glycolytic enzymes in OC samples (n = 428) from TCGA. Data are presented as the means ± SEM. *P < 0.05; ***P < 0.001, ****P < 0.0001.

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