Fig. 5: Characterizing the regulation of SOX2 and NTRK2.
From: Characterizing resistant cellular states in nasopharyngeal carcinoma during EBV lytic induction
A Western blot showing TrkB, SOX2, E-cad (EMT-related marker), pERK (MAPK-related marker), and pS6 (PI3K-related marker) abundances in NPC43 cells undergoing SOX2-KD or NTRK2-KD. B Heatmap showing the activity of predicted TFs in different conditions. Predicted TFs were inferred from scRNA-seq data with the SENIC algorithm. C Rank plots showing the most specified TFs in NR cells at UT, T24, and T48. SOX2 or NTRK2-related TFs were highlighted. D Network showing how SOX2 is connected with NTRK2. TFs that are activated in NR cells were visualized in the network. E FACS plots showing the detection of SOX2 and TrkB in NP460 cells with SOX2 overexpression vector. F Western blot showing TrkB and SOX2 in NP460 cells with SOX2 overexpression.
