Fig. 6: NTRK2 and SOX2 serve as robust features of NR cells across different NPC models.
From: Characterizing resistant cellular states in nasopharyngeal carcinoma during EBV lytic induction
A Heatmap displaying the top features correlated with NTRK2 expression, including genes and pathways. Only features recurrent across multiple datasets are shown in the heatmap. B UMAP of integrated scRNA-seq data from C666-1, with cells colored by treatment conditions and cellular states. Expression levels of NTRK2 and SOX2 are also visualized on the UMAP. C UMAP illustrating representative pathway terms associated with different cellular states. Stemness terms are enriched in NR-like cells; cytolysis and response to UV-B are enriched in cytolysis cells; unfolded protein response and inhibitory synaptic assembly are enriched in Prelytic cells. D Violin plot showing scores for EMT, Adhesion-related, hypoxia, and stress pathways. Only UT and T48 samples are included to compare NR-like cells. E UMAP shows the density of EBV gene detection and the expression of the lytic activation marker BZLF1.
