Fig. 2: Master TFs in CRC, identified from LUAD-SE genes are frequently overexpressed in human LUAD and are correlated with poor prognosis in LUAD patients. | Oncogenesis

Fig. 2: Master TFs in CRC, identified from LUAD-SE genes are frequently overexpressed in human LUAD and are correlated with poor prognosis in LUAD patients.

From: Aberrant super-enhancer landscape reveals core transcriptional regulatory circuitry in lung adenocarcinoma

Fig. 2

A Experimental validation for LUAD cell circuitry. Core regulatory circuit containing ELF3, EHF, and TGIF1 for LUAD cell lines, A549 and PC-9. B Intersections of TFs between two individual LUAD cell lines, A549 and PC-9, identified by CRC models. C The expression levels of selected TFs in tumor or normal tissues of patients with LUAD based on the TCGA illumina HiSeq RNA-Seq data. The x-axis represents the different tissues of LUAD patients and the y-axis represents expression read counts of TCGA. D Kaplan–Meier survival analysis with TCGA datasets indicates that higher ELF3 (p = 0.011), EHF (p = 0.00024), and TGIF1 (p = 0.00028) expression is associated with a worse overall survival in patients with LUAD. E ChIP-seq occupancy profiles of H3K27Ac at the normal adult lung, A549 cell line and PC-9 cell line. H3K27Ac ChIP-seq signal was highly enriched in the ELF3, EHF and TGIF1 genomic loci of A549 and PC-9 cells but not the normal liver. TCGA The Cancer Genome Atlas.

Back to article page