Fig. 2: Structural features of UBE2M and UBE2F.
From: Discovery of neddylation E2s inhibitors with therapeutic activity
A Classification of E2 conjugating enzyme based on N and C terminal extensions. B The crystal structure of UBE2M in green (PDB: 1Y8X) and UBE2F in the sky (PDB: 3FN1). C Virtually identified V30, F56, and C116 pockets of UBE2F for inhibitor binding. D Principle of developing DI-591 and (E) Proposed idea of developing E2 targeting inhibitor.
