Fig. 7
From: Methylation across the central dogma in health and diseases: new therapeutic strategies
Histone, nonhistone protein, and RNA methylation changes with age. a Alterations in histone and nonhistone protein methylation and 3D genome structure with age. G9a/GLP-mediated methylation of Lamin B1 (LMNB1) promotes heterochromatin assembly at the nuclear periphery and formation of lamina-associated domains (LADs) in young cells, which ensures transcriptional silence; whereas defects in both histone methylation (H3K9me2/3) and nonhistone protein methylation are associated with chromatin detachment from the nuclear lamina and a shift to a euchromatin state. b Overall changes of m6A modification with age in different tissues including brain, peripheral blood mononuclear cells, ovary, and intestine, and crucial age-related targets. Changes in the expression of writers or erasers account for the methylation fluctuation. Although the m6A level and expression of modifiers do not differ significantly between young and old mouse hearts, they do show aging-related differences in response to acute cardiac ischemia/reperfusion injury, which may be associated with reduced tolerance to ischemic injury with age
