Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: NAD+ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension

Fig. 2

NAD+ level of aortas from hypertensive patients and AngII-induced hypertensive mice is reduced. a, b Representative images of thoracic aorta sections from hypertensive patients (n = 5) and healthy subjects (n = 5) stained with Von Kossa. Scale bar = 250 μm. c NAD+ level was measured in thoracic aorta of hypertensive patients and healthy subjects (n = 5). d–g NAD+, NMN, NR and Nam levels in mice aortas were detected by HPLC-MS (n = 5). h, i The change of SBP and DBP was detected by a tail-cuff plethysmography system (n = 5). j, k NAD+ and NMN levels in mice aortas of different groups were detected by HPLC-MS (n = 5). l In vivo aortic pulse wave velocity was measured by Doppler (n = 5). m The aortic ring assay was performed to evaluate the Ach-vasodilation (n = 5). *p < 0.05, **p < 0.01, ***p < 0.001

Back to article page