Fig. 7
From: The multiple roles of interferon regulatory factor family in health and disease
The potential role of IRFs in infectious diseases. a The roles of IRFs in viral infections. IRF1 can regulate IFN and inflammasome to fight viral infections, while it also induces cell PANoptosis and virus immune evasion. IRF2, IRF3, IRF4,IRF5, IRF7, and IRF9 play protective roles to prevent viral infections. b The roles of IRFs in bacterial and parasitic infections. IRF1, IRF4, and IRF8 prevent host aginst bacterial infections. IRF3, IRF5, and IRF7 are double-edged swords in bacterial and parasitic infections
