Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: Clinical investigation on nebulized human umbilical cord MSC-derived extracellular vesicles for pulmonary fibrosis treatment

Fig. 5

Bio-distribution of nebulized hUCMSC-EVs. a A schematic representation of the animal experiments is provided. On day 1, mice were administered intratracheally with labeled UCMSC-EVs (1×108 per mouse, n = 72). The living imaging and sacrificed organ imaging were collected according to the time point. The image was created using MedPeer. b Biodistribution of DiR-labeled hUCMSC-EVs in vivo continuously until 28 d post-nebulization. c Biodistribution of DiR-labeled hUCMSC-EVs in vitro continuously until 28 d post-nebulization. The list of terms represents the layout of isolated organs. d Statistical curves depicting the time-dependent distribution of signals from both in vivo and ex vivo imaging. Data include separate analyses for male and female groups, as well as signal distribution across different organs

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