Abstract
Study design
Systematic review.
Objectives
The aim of this systematic review is to summarize the incidence of complications, to relate complication incidence to procedures performed, to assess the impact of the year of study publication and follow-up duration on complication incidence.
Methods
The authors conducted the Cochrane Central Register of Controlled Trials, PubMed, and EMBASE searches for relevant literatures. The incidence of complications was summarized. Correlation of the incidence with year of study publications, follow-up duration, and the surgical outcome was statistically evaluated.
Results
A total of 16 studies met our inclusion criteria, including 475 patients. All of these studies were retrospective case series. The mean age of patients ranged from 55 to 64 years. Average follow-up duration ranged from 26 to 65 months. Partial patients in four studies underwent surgeries and reserved posterior structure of the spinal canal. The others underwent operations removing posterior structure of spinal canal. The mean recovery rate from each individual study varied between 31 and 68% and the pooled neurologic function recovery rate was 53% (95% CI: 43–62%). The mean complication rate was 24%. Cerebrospinal fluid leakage was the most reported postoperative complication (19%), then neurologic deterioration (5%). Other complications included local infections, wound dehiscence, increased kyphotic deformity, an hematoma.
Conclusions
Operations removing posterior structure of spinal canal are the main technique to decompress spinal cord. Cerebrospinal fluid leakage and postoperative neurologic deterioration were the most reported complications.
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Acknowledgements
We acknowledge the statistical advice from Dr. Xiaoxiao Wang (Research Center of Clinical Epidemiology, Peking University Third Hospital). We thank Angela Morben, DVM, ELS, from Liwen Bianji, Edanz Editing China (www.liwenbianji.cn/ac), for editing the English text of a draft of this manuscript. This study was supported by the Beijing Natural Science Foundation (7174366).
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Hou, X., Chen, Z., Sun, C. et al. A systematic review of complications in thoracic spine surgery for ossification of ligamentum flavum. Spinal Cord 56, 301–307 (2018). https://doi.org/10.1038/s41393-017-0040-4
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DOI: https://doi.org/10.1038/s41393-017-0040-4
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