Fig. 3: Manhattan plots and QQ plots of the genome-wide association studies. | The Pharmacogenomics Journal

Fig. 3: Manhattan plots and QQ plots of the genome-wide association studies.

From: Rapid response to the alpha-1 adrenergic agent phenylephrine in the perioperative period is impacted by genomics and ancestry

Fig. 3

A GWAS performed on Δ SBP with the whole cohort. The red horizontal line denotes the genome-wide significance threshold for p-values (5e−8) while the blue horizontal line denotes a p-value threshold of 1e−5. The top SNP is rs145337816, located on chromosome 5, at locus 117211218 (in hg19 coordinates). The minor allele frequency is 0.46%, the imputation info score is 0.909. The association p-value is 2.02e−8. Lambda-gc = 1.0059. B GWAS performed on Δ SBP with European Americans. The top SNP is rs188427942, located on chromosome 5, at locus 122900413 (in hg19 coordinates). The minor allele frequency is 1.16 % in EA (0.57% in the whole cohort), the imputation info score is 0.759. The association p-value is 5.26e−8. Lambda-gc = 0.9976. C performed on Δ SBP with Hispanic/Latinos. The top SNP is rs6657443, located on chromosome 1, at locus 209189265 (in hg19 coordinates). The minor allele frequency is 7.63 % in HA (8.83% in the whole cohort), the imputation info score is 0.948. The association p-value is 7.62e−9. Lambda-gc = 1.0027.

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