Fig. 3: Enrichment analysis of genes in thistle2 module that are differentially expressed in alcoholics and controls. | Translational Psychiatry

Fig. 3: Enrichment analysis of genes in thistle2 module that are differentially expressed in alcoholics and controls.

From: Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism

Fig. 3

a More than 50% of genes in calcium signaling pathways were found to be downregulated in the thistle2 module. b Enrichment analysis for GO:BP terms showed downregulation of genes related to response to nicotine and postsynaptic potential. c Nearly 15 genes mapped to network related to amino-acid metabolism with many genes that were involved in G-protein coupled receptor signaling, calcium signaling and opioid signaling pathway. The nominally significant genes in the UKBB-alc and PGC-SUD GWAS are marked with red boundaries (ADCY5 P = 7.07 × 10−7 in UKBB-AC, ADCY7, P = 2.2 × 10−4 in UKBB-AC), IL12B, P = 1.1 × 10−2 in PGC-AD, PIK3C2G, P = 6.8 × 10−3 in UKBB-AC, PIK3R4, P = 3.4 × 10−2 in PGC-AD, CHRNA6 in UKBB-AC P = 7.60 × 10−3, CHRNA2 in PGC-AD P = 1.4 × 10−2, MN1 in PGC-AD P = 9.1 × 10−3 and HAPLN1 in UKBB-AC P = 1.9 × 10−2)

Back to article page