Table 2 Results of GWAS enrichment analysis in modules correlated with alcohol dependence and alcohol consumption

From: Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism

 

RNA-Seq data (N = 138)

GWAS data

 

Module trait correlation

GWAS P 0.05, eQTL P < 5 × 10−8

ID

AD

P

Audit

P

AC

P

PGC-AD

UKBB-AC

TAG-CPD

Thistle2

−0.28

9.00E-04

−0.25

3.00E-03

−0.22

9.00E-03

1.50E-02a

1.30E-02a

5.52E-01a

Brown4

0.18

4.00E-02

0.14

1.00E-01

0.12

1.00E-01

4.20E-03b

2.28E-01b

4.81E-03b

  1. AD alcohol dependence, Audit audit scores, AC alcohol consumption
  2. a Permuted P value for the left-tail Fisher’s exact test (under-enriched)
  3. b Permuted P value to test right-tail Fisher’s exact test (over-enriched)
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