Fig. 1: Systemic naltrexone pretreatment blocks the antidepressant-like actions of ketamine. | Translational Psychiatry

Fig. 1: Systemic naltrexone pretreatment blocks the antidepressant-like actions of ketamine.

From: The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions

Fig. 1

A Schematic timeline of systemic naltrexone pretreatment, ketamine treatment, and behavioral testing. Systemic naltrexone pretreatment blocks (B) the reduction in immobility time in the FST (ketamine x naltrexone interaction F(1, 28) = 8.420, p = 0.0072; see Supplementary Table S1 for full statistical results), C the increase in sniffing time in the FUST (interaction F(1, 28) = 5.304, p = 0.0289), and (D) the reduction of latency to feed in the NSFT induced by ketamine (interaction F(1, 28) = 4.284, p = 0.0478), without affecting locomotor activity (interaction F(1, 28) = 2.308, p = 0.1399) (E). Two-way ANOVA followed by Sidak’s post hoc test. n = 8/group. Post hoc significant effects indicated as: *p < 0.05, ***p < 0.001. ns nonsignificant, SAL saline, NTX naltrexone, FST forced swim test, FUST female urine sniffing test, NSFT novelty suppressed feeding test, LMA locomotion.

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