Fig. 2: LPS and heroin exposure synergistically alter the NAc transcriptome. | Translational Psychiatry

Fig. 2: LPS and heroin exposure synergistically alter the NAc transcriptome.

From: Neuroinflammatory history results in overlapping transcriptional signatures with heroin exposure in the nucleus accumbens and alters responsiveness to heroin in male rats

Fig. 2

Venn diagram of total differential expressed genes (DEGs) regulated in the NAc by LPS-Saline and/or Saline-Heroin (A); LPS-Saline and/or LPS-Heroin (B); and Saline-Heroin and/or LPS-Heroin (C). In the intersection, in red, are represented the genes co-regulated in both groups; the asterisk (*) represent a p < 0.0001 obtained with the Fisher exact test. RRHO plots comparing all gene expression data between LPS-Saline and Saline-Heroin (D); LPS-Saline and LPS-Heroin (E); or Saline-Heroin and LPS-Heroin (F). As indicated by white arrows, the upper right quadrant represents genes down-regulated in both groups while lower left quadrant represents genes up-regulated in both groups. G Venn diagram of DEGs regulated by LPS-Saline, Saline-Heroin, and/or LPS-Heroin in the NAc. Reds represents the number of genes co-regulated across all experimental groups. H Alluvial plot showing the flow of gene expression clusters through Saline-Heroin (S_H), LPS-Saline (LPS_S) and LPS-Heroin (LPS_H) conditions. Bar graphs represent Gene ontology (I) and KEGG pathway (J) analysis of co-regulated genes from LPS-Saline, Saline-Heroin, and LPS-Heroin conditions.

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