Table 1 Inhibition of SARS-CoV-2 3CLpro by Shuanghuanglian preparations as well as their ingredients, and the determined content of chlorogenic acid, phillyrin, baicalin, and baicalein in Shuanghuanglian preparations.
From: Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients
Entities | IC50 | Chlorogenic acid | Phillyrin | Baicalin | Baicalein |
|---|---|---|---|---|---|
Oral liquid 1a | 0.090 ± 0.004 µL/mL | 0.72 ± 0.01 mg/mL | 0.29 ± 0.01 mg/mL | 12.72 ± 0.30 mg/mL | 0.12 ± 0.00 mg/mL |
Oral liquid 2a | 0.064 ± 0.011 µL/mL | 0.78 ± 0.01 mg/mL | 0.32 ± 0.01 mg/mL | 12.78 ± 0.18 mg/mL | 0.06 ± 0.00 mg/mL |
Oral liquid 3a | 0.076 ± 0.007 µL/mL | 0.78 ± 0.01 mg/mL | 0.28 ± 0.01 mg/mL | 17.52 ± 0.17 mg/mL | 0.22 ± 0.00 mg/mL |
Lyophilized powdera | 0.010 ± 0.001 mg/mL | 19.36 ± 0.35 mg/g | 2.92 ± 0.05 mg/g | 274.08 ± 2.82 mg/g | 1.87 ± 0.04 mg/g |
Chlorogenic acid | 39.48 ± 5.51 µM | ||||
Phillyrin | 7.8% inhibition @ 10 µM | ||||
Baicalin | 6.41 ± 0.95 µM | ||||
Baicalein | 0.94 ± 0.20 µM |
