Fig. 8 | Bone Research

Fig. 8

From: HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation

Fig. 8

Model of the distinct function of HOTAIR in BMSC osteogenic differentiation and osteogenesis. In BMSCs, nuclear HOTAIR interacts with EZH2 and enhances the modification of H3K27me3 in the promoter regions of Runx2 and Sp7 genes, which leads to the inhibition of osteogenic differentiation of BMSCs. In osteoblasts, HOTAIR is located in the cytoplasm to sponge miR-214 and promotes osteoblast function by alleviating Atf4 translation. Moreover, HuR mediates the nucleocytoplasmic translocation of HOTAIR in the progression of osteogenic differentiation of BMSCs

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