Fig. 4: Immumofluorescence analysis of baseline biopsies.

Representative images of baseline biopsies stained for a blood vessels (CD31), b proliferating cells (Ki67) and e CD8 + T-cell activation status (Granzyme B and PD-1). Whole slides were scanned and quantified using automated computer image analysis on HALO (c, d, f–h two-tailed Student t test).