Fig. 6: The antitumor activity of MMAE-based chemotherapy is not weakened by pretreatment with lithium.
From: Chemotherapy-induced neuropathy in monomethyl Auristatin E treatment: prevention by lithium
a Representative images of xenograft tumor of MDA-MB-231 cells induced in Balb/c nude mice, showing reduction in both MMAE and LiCl+MMAE groups in comparison to the control. b Time course of tumor size during the indicated treatments, showing that lithium does not harm the antitumoral activity of MMAE. c Size of excised tumors after indicated treatments. MMAE and LiCl+MMAE (n = 7 each group) had a reduction in tumor, with size final comparable to the saline (n = 5) treated animals (p < 0.01). d Representative image of tumors stained with TUNEL, showing presence of apoptosis in tumors from MMAE and LiCl+MMAE treated animals. e Graphic shows number of TUNEL positive cells per mm2. MMAE and LiCl+MMAE groups presented a significantly higher number of stained cells compared to the control group (p < 0.01 and p < 0.0001, respectively; n = 10–15 tissue sections each group) indicating cellular death in tumors treated with chemotherapy.
