Fig. 2: TNFR1 and ZBP1 synergize to drive skin inflammation in FADDE-KO mice. | Cell Death & Differentiation

Fig. 2: TNFR1 and ZBP1 synergize to drive skin inflammation in FADDE-KO mice.

From: ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis

Fig. 2

A Representative photographs of FADDE-KO TNFR1E-KO Zbp1−/WT (n = 15), FADDE-KO TNFR1E-KO Zbp1−/− (n = 27)  and control  (n = 22) mice. B Graph depicting lesion onset of mice with indicated genotypes. C Representative images from skin sections stained with H&E (Scale bars = 100 µM, n = 9 for FADDE-KO TNFR1E-KO Zbp1−/WT, n = 10 for FADDE-KO TNFR1E-KO Zbp1−/−, n = 7 for control) or immunostained with K10, K14 and K6 (Scale bars = 50 µM, n = 3 for FADDE-KO TNFR1E-KO Zbp1−/WT n = 5 for FADDE-KO TNFR1E-KO Zbp1−/−, n = 6 for control). D Graph depicting epidermal thickness of mice with indicated genotypes. E Model depicting pathology induced by loss of FADD and loss of FADD in combination with loss of TNFR1 in keratinocytes.

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