Fig. 7: IRF-1 inhibits tumour metastases in vivo by affecting MIR17HG expression and Wnt/β-catenin signalling. | Cell Death & Disease

Fig. 7: IRF-1 inhibits tumour metastases in vivo by affecting MIR17HG expression and Wnt/β-catenin signalling.

From: MIR17HG-miR-18a/19a axis, regulated by interferon regulatory factor-1, promotes gastric cancer metastasis via Wnt/β-catenin signalling

Fig. 7

a Average body weights of mice per group throughout the experiment. b H&E staining of lung tissue and number of nodules per mouse with lung metastases in each group. Scale bars, 200 μm (above) and 50 μm (below). c H&E staining of liver tissue and number of mice with liver metastases in each group. Scale bars, 100 μm (above) and 25 μm (below). d The lung metastasis nodules of the Lv-IRF-1 and Lv-IRF-1 + Dox groups were carefully stripped, and the expression levels of miR-18a and miR-19a were analysed by qRT-PCR. *P < 0.05, as determined by two-tailed unpaired Student’s t test. The data in a, b, c and d are presented as the means ± SDs. e Lung and f liver tissue, the expression of IRF-1, β-catenin and C-Myc were analysed by immunohistochemistry. N = 4 biological replicates of each experiment. Scale bars, 100 μm

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