Fig. 8: Schematic diagram of the results of our study. | Cell Death & Disease

Fig. 8: Schematic diagram of the results of our study.

From: MIR17HG-miR-18a/19a axis, regulated by interferon regulatory factor-1, promotes gastric cancer metastasis via Wnt/β-catenin signalling

Fig. 8

When IRF-1 expression in GC is low, large numbers of miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92–1 are derived from MIR17HG, of which miR-18a and miR-19a decrease SMAD2 protein expression by inhibiting its promoter activity, attenuating its inhibitory effect on β-catenin. The increased expression of Wnt/β-catenin signalling elements, such as C-Myc, Axin2, etc., increases the metastasis of GC. When IRF-1 expression is increased, MIR17HG promoter activity is inhibited and the expression of miRNAs from MIR17HG is reduced. Subsequently, the inhibitory effect of miR-18a and miR-19a on SMAD2 promoter is attenuated. The increased expression of SMAD2 leads to it binding β-catenin and inhibiting its activity, thereby attenuating Wnt/β-catenin signalling and inhibiting GC metastasis

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