Fig. 6: CPCs-Ex promoted CVB3-induced apoptosis and VP1 expression in Akt1, Akt2, 4EBP1, and p70S6K overexpression groups | Cell Death & Disease

Fig. 6: CPCs-Ex promoted CVB3-induced apoptosis and VP1 expression in Akt1, Akt2, 4EBP1, and p70S6K overexpression groups

From: Exosomes derived from cardiac progenitor cells attenuate CVB3-induced apoptosis via abrogating the proliferation of CVB3 and modulating the mTOR signaling pathways

Fig. 6

a Establishment of stable cell lines overexpressing 4EBP1, p70S6K, Akt1, and Akt2, respectively. The expressions of Akt1, Akt2, 4EBP1, and p70S6K were determined by western blot analysis. b Apoptosis rate of H9C2 cells in different groups analyzed by FCM (mean ± SEM, n = 3, one-way ANOVA). c, d VP1 expression of H9C2 cells in different groups analyzed by RT-PCR and western blot (mean ± SEM, n = 3, one-way ANOVA). *P < 0.05 and **P < 0.01 vs. Control

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