Fig. 4: SPOP insufficiency promotes pancreatic cancer cell proliferation in vivo.
From: SPOP suppresses pancreatic cancer progression by promoting the degradation of NANOG
a Mean tumor volume measured by caliper on the indicated days. Tumor volume in the curve was expressed as mean ± S.D. (n = 4). **P < 0.01. b Photographs showing the appearance of tumors in tumor-bearing nude mice. c Photographs of tumors excised 28 days after inoculation of stably transfected cells into nude mice. d Tumor weight and tumor/body weight ratios of each nude mouse at the end of 28 days. Tumor weight in the curve was expressed as mean ± S.D. (n = 4). **P < 0.01. e H&E staining and IHC analysis of SPOP in tissue samples from xenograft models. Scale bars = 100 μm. f Western blot analysis was performed to characterize the expression of some cell cycle regulatory proteins and key metastasis-related proteins in SW1990-Control (left three lanes) and SW1990-shSPOP groups (right three lanes)
