Table 1 Correlation of clinicopathologic features with METTL3 expression in gastric cancer tissues.

From: N6-methyladenosine-dependent pri-miR-17-92 maturation suppresses PTEN/TMEM127 and promotes sensitivity to everolimus in gastric cancer

 

Numbera

METTL3 expression

P valueb

Clinicopathological features

Lowa

Higha

Gender

   

0.6497

     Male

68 (78.16%)

29 (42.65%)

39 (57.35%)

 

     Female

19 (21.84%)

7 (36.85%)

12 (63.15%)

 

Age

   

0.8096

     ≥65

18 (20.69%)

7 (38.89%)

11 (61.11%)

 

     <65

69 (79.31%)

29 (42.03%)

40 (57.97%)

 

Stage

   

0.0056**

     I + II

29 (33.33%)

18 (62.07%)

11 (39.93%)

 

     III + IV

58 (66.67%)

18 (31.03%)

40 (68.97%)

 

Tumor invasion

   

0.5317

     T1 or T2 or T3

30 (34.48%)

12 (40.00%)

18 (60.00%)

 

     T4

57 (65.52%)

24 (42.11%)

33 (57.89%)

 

Lymph node involvement

   

0.0251*

     Yes

62 (71.26%)

21 (33.87%)

41 (66.13%)

 

     No

25 (28.74%)

15 (60.00%)

10 (40.00%)

 

Metastasis

   

0.0639

     M0

68 (78.16%)

32 (47.06%)

36 (52.94%)

 

     M1

19 (21.84%)

4 (21.05%)

15 (78.95%)

 

Differentiation

   

0.2849

     Poorly

47 (54.02%)

17 (36.17%)

30 (63.83%)

 

     Well

40 (45.98%)

19 (47.50%)

21 (52.50%)

 

Microvascular invasion

   

0.0346*

     Present

16 (28.07%)

4 (25.00%)

12 (75.00%)

 

     Absent

41 (71.93%)

23 (56.10%)

18 (43.90%)

 
  1. aData are presented as numbers (proportions).
  2. bP values were calculated by Chi-square test or Fisher’s exact test.
  3. *P < 0.05; **P < 0.01.