Fig. 7: Cordycepin, cDDP, and the combination of the two inhibit the PI3K/AKT signaling pathway in K180 cells. | Cell Death & Disease

Fig. 7: Cordycepin, cDDP, and the combination of the two inhibit the PI3K/AKT signaling pathway in K180 cells.

From: Cordycepin enhances the chemosensitivity of esophageal cancer cells to cisplatin by inducing the activation of AMPK and suppressing the AKT signaling pathway

Fig. 7

Protein expression levels of p-PI3K, PI3K, p-Akt, Akt, Caspase-3, cleaved Caspase-3, Bcl-2, Bax, and GAPDH in K180 cells treated with either cordycepin (50 μM) or cDDP (2 μM) alone, or cDDP (1 μM) and cordycepin (25 μM) for 48 h (A). The histogram describes the relative gray values of related proteins measured using Image J (B–H). All data are shown as the (mean ± SD) of three independent experiments. **p < 0.01 or ***p < 0.001 compared with the control group. cDDP cisplatin, Cor cordycepin, P13K phosphatidylinositol 3-kinase, GAPDH glyceraldehyde 3-phosphate dehydrogenase.

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