Fig. 7: Exosomes from STIM1-KO-MDA-MB-231 breast cancer cells contain higher levels of miR-145, which targets IRS1 and its downstream signal to suppress tube formation of vascular endothelial cells, resulting in anti-angiogenesis effect.
From: STIM1 promotes angiogenesis by reducing exosomal miR-145 in breast cancer MDA-MB-231 cells
Predicted anti-angiogenic mechanism of exosomal miR-145 from STIM1-KO-MDA-MB-231 cells via targeting IRS1.
