Fig. 1: Genetic alterations of ZNF750 across 612 ESCC genomes. | Cell Death & Disease

Fig. 1: Genetic alterations of ZNF750 across 612 ESCC genomes.

From: Decreased ZNF750 promotes angiogenesis in a paracrine manner via activating DANCR/miR-4707-3p/FOXC2 axis in esophageal squamous cell carcinoma

Fig. 1

a The mutation sites and types in CDS region of ZNF750 across 612 ESCC genomes. b The significant focal SCNA filtered by GISTCI across 508 ESCC genomes. c Heatmap of CNV log2 ratio of read coverage across 71 ESCC individuals in 17q25.3 and ZNF750 regions (upper) and detected significant deletion of ZNF750 (bottom). d, e ZNF750 copy number was assayed by qRT-PCR in BDESCC0122, BDESCC0481, BDESCC0177 and BDESCC0189. RPPH1 was used as a normal reference, and TMC8 (located near this region) was used as a focal CNA control. f–h Kaplan–Meier survival analysis between ESCC patients with ZNF750-mut and ZNF750-wt, ESCC patients with ZNF750-wt and ZNF750-del, and ESCC patients with ZNF750-wt and ZNF750-Val (ZNF750-mut + ZNF750-del). The horizontal axis is the survival time and the vertical axis is the percentage of survival cases in total cases. Every cross on the survival curves stands for censored data. Log-rank test P-value, Cox regression P-value, Hazard Ratio and 95% CI are displayed on the graph. i The mRNA of ZNF750 was significantly decreased in ESCC tissue compared with paired normal tissue in 97 cases. Data represent the mean ± SD. All assays were performed in triplicate. Statistical analysis was performed with a two-side paired-t test. **p < 0.01, ***p < 0.0001.

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